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In addition to directly inhibiting tyrosinase activity, 4,4′-dihyldroxybiphenyl was also found to suppress several cellular key parameters in the melanogenic pathway by downregulating the cAMP-dependent protein kinase K signaling pathway and decreasing gene expression of microphthalmia transcription factor, which in turn suppressed tyrosinase expression [153]

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The legal status of BPC-157 in the U.S